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Zhang et al. BMC Nephrology 2013, 14:252 http://biomedcentral/1471-2369/14/RESEARCH ARTICLEOpen AccessCross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patientsKunYing Zhang1,2,3, YinHui Li5, XuYang Cheng1,2,3, Li Liu1,two,three, WenYing Bai6, WeiYa Guo7, LeiYun Wu8 and Li Zuo1,2,three,4*AbstractBackground: Both vitamin C deficiency and inflammation are prevalent in maintenance hemodialysis (MHD) patients.Formula of Boc-(S)-3-Amino-3-phenylpropanal In this study, we aimed to elucidate the impact of oral vitamin C supplementation on inflammatory status in MHD sufferers with low vitamin C level and high hypersensitive C-reactive protein (hs-CRP) level.Boc-amido-PEG9-amine Order Strategies: A total of 128 patients were recruited in our present study.PMID:33563062 Individuals were divided into two groups. In group 1 (n = 67), sufferers had been orally administered with 200 mg/day vitamin C within the 1st 3 months, and after that the vitamin C supplementation was withdrawn within the subsequent three months. In group two (n = 61), sufferers have been not offered vitamin C within the 1st three months, then they were orally administered with 200 mg/day within the subsequent 3 months. Levels of hs-CRP, prealbumin, albumin and hemoglobin also because the EPO resistance index (ERI) were determined at the baseline and every 3 months throughout the study. Plasma vitamin C level was determined by high-performance liquid chromatography with UV detection. Final results: Among the 128 individuals, 28 of them dropped out of the study prior to completion. Consequently, a total of one hundred patients (group 1: n = 48; group two: n = 52) were included in the final evaluation. At the baseline, the plasma vitamin C amount of all patients was significantly less than four g/mL. However, this proportion was decreased to 20 just after the vitamin C supplementation for three months. Compared with individuals with no the vitamin C supplementation, a decreased degree of hs-CRP and an enhanced level of prealbumin have been induced by the vitamin C supplementation for 3 months in both groups. Nonetheless, levels of these biomarkers returned to their original state following the supplementation was withdrawn. Similar effective effects on plasma albumin, hemoglobin and ERI response to vitamin C supplementation have been observed within the two groups devoid of statistical significance. Conclusions:.
