Product Name :
PAK2 Recombinant Rabbit Monoclonal Antibody [JB41-84]

Predicted band size :
58 kDa

Observed band size :
58 kDa

Synonyms:
C-t-PAK2 antibody CB422 antibody EC 2.7.11.1 antibody Gamma PAK antibody Gamma-PAK antibody hPAK65 antibody Kinase antibody p21 (CDKN1A) activated kinase 2 antibody p21 (CDKN1A)-activated kinase 2a antibody p21 activated kinase 2 antibody 展开

Function :
Three recently identified isoforms of serine/threonine kinases, designated αPAK p68, βPAK p65 and γPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase STE20, involved in pheromone signaling.3-Bromo-6-fluoropicolinic acid Data Sheet The α, β, and γPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.2,4-Dichloro-5,6-dimethylpyrimidine Formula

Antibody Type:
Recombinant Rabbit monoclonal Antibody

Immunogen :
Synthetic peptide within N-terminal Human PAK2 .PMID:33649698

Species reactivity:
Human, Mouse, Rat

Verify application:
WB, IHC-P, FC, IF-Cell, IF-Tissue

Coupling :
unconjugated

Clone number:
JB41-84

RRID:
AB_3070787

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 58 kDa

Positive control :
Mouse thymus tissue lysate, MCF-7 cell lysate, A431, SiHa, human colon cancer tissue, human liver tissue, rat kidney tissue.